Advancing Epigenetics Towards Systems Biology

Juan M. Vaquerizas

Max Planck Institute for Molecular Biomedicine, Münster, Germany

Epigenomics analysis of mono-allelic gene expression

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juan vaquerizasjuan vaquerizas group

Mono-allelic gene expression is a molecular phenomenon by which gene products are produced from a single allele in each cell. This has been shown to be a crucial aspect of the epigenetics regulation of different biological systems such as X chromosome inactivation in mammalian females, or the regulation of pluripotency in stem cells. We are interested in investigating mono-allelic gene expression in pathogens, where it plays a key role during the infection process. To do so, we employ high-throughput genome-wide techniques, such as ChIP-seq or RNA-seq, to examine chromatin and gene expression changes that occur in the pathogen¹s genome over the course of an infection. Our goal in doing these experiments is to understand the molecular mechanisms that control mono-allelic gene expression and how they are regulated, which, in turn, will help us suggest new therapeutic approaches to treat these infections.

People involved:

  • Rocio Enriquez-Gasca, PhD student
  • Anna-Wiebke Meyer, research assistant

Latest publications

Chromatin Architecture Emerges during Zygotic Genome Activation Independent of Transcription.

28388407 - 2017-04-08
Cell 2017 Apr 6;169(2):216-228.e19

Hug CB, Grimaldi AG, Kruse K, Vaquerizas JM

Developmental biology: Panoramic views of the early epigenome.

27626372 - 2016-09-15
Nature 2016 Sep 14;

Vaquerizas JM, Torres-Padilla ME

Dual randomization of oligonucleotides to reduce the bias in ribosome-profiling libraries.

27450428 - 2016-07-28
Methods 2016 Jul 19;

Lecanda A, Nilges BS, Sharma P, Nedialkova DD, Schwarz J, Vaquerizas JM, Leidel SA

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