Advancing Epigenetics Towards Systems Biology

Elizabeth Bayne

Institute of Cell Biology, University of Edinburgh, United Kingdom.

Role of small RNAs in chromatin modification

Web Page

elizabeth bayneelizabeth bayne group

We are interested in understanding the molecular mechanisms by which small RNAs can direct epigenetic changes via chromatin modification. Our current research is aimed at dissecting one of the best characterised examples of this phenomenon: RNAi-dependent heterochromatin assembly in the fission yeast, Schizosaccharomyces pombe. We recently identified a novel epigenetic regulator named Stc1, which appears to play a key role in coupling RNAi to chromatin modification in this system. Funding from EpiGeneSys is supporting a project aimed at characterising, quantifying and modelling the interactions of Stc1 with its binding partners and with chromatin, with a view to understanding the dynamic process by which Stc1 mediates the recruitment of chromatin modifiers to sites of active RNAi.

People involved:

  • Laure Verrier, Postdoc
  • Sreerekha Pillai, PhD student/Research assistant

Latest publications

The Discovery, Distribution, and Evolution of Viruses Associated with Drosophila melanogaster.

26172158 - 2015-07-15
PLoS Biol 2015 Jul;13(7):e1002210

Webster CL, Waldron FM, Robertson S, Crowson D, Ferrari G, Quintana JF, Brouqui JM, Bayne EH, Longdon B, Buck AH, Lazzaro BP, Akorli J, Haddrill PR, Obbard DJ

Global regulation of heterochromatin spreading by Leo1.

25972440 - 2015-05-15
Open Biol 2015 May;5(5)

Verrier L, Taglini F, Barrales RR, Webb S, Urano T, Braun S, Bayne EH

A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast.

25274039 - 2014-10-03
Genome Biol 2014 Oct 2;15(10):481

Bayne EH, Bijos DA, White SA, de Lima Alves F, Rappsilber J, Allshire RC

View all their publications