Advancing Epigenetics Towards Systems Biology

Jérôme Déjardin

Department Genome Dynamics, Institute of Human Genetics, Montpellier, France

Biology of Repetitive Sequences       

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jerome dejardinjerome dejardin group

To understand how heterochromatin acts at the molecular level, we are looking at the effect of abrogating important heterochromatic activities, such as histone and/or DNA methyl-transferases, on the overall composition of key heterochromatic loci (telomeres, pericentromeres and rDNA). In particular, we are interested in:

(i) How telomere compositional changes upon loss of heterochromatin function can explain the appearance of the ALT (Alternative Lengthening of Telomeres) pathway observed in certain cancers.

(ii) How the situation at ALT telomeres can be compared to the changes observed at human satellite 2 sequences upon loss of DNA methylation in ICF cells. Indeed, satellite 2 regions recombine aberrantly and localize to PML bodies in ICF cells, a "behavior" also observed in the case of ALT telomeres.

(iii) How pericentric heterochromatin is regulated by such enzymatic activities during development, differentiation and why such regulation matters for genome stability.

(iv) Characterizing a new heterochromatin protein which possibly links DNA methylation and non-coding RNAs.

(v) How is rDNA expression regulated?

Latest publications

The molecular basis of the organization of repetitive DNA-containing constitutive heterochromatin in mammals.

28078514 - 2017-01-13
Chromosome Res 2017 Mar;25(1):77-87

Nishibuchi G, Déjardin J

The cell proliferation antigen Ki-67 organises heterochromatin.

26949251 - 2016-03-08
Elife 2016 Mar 7;5

Sobecki M, Mrouj K, Camasses A, Parisis N, Nicolas E, Llères D, Gerbe F, Prieto S, Krasinska L, David A, Eguren M, Birling MC, Urbach S, Hem S, Déjardin J, Malumbres M, Jay P, Dulic V, Lafontaine DL, Feil RP, Fisher D

Switching between Epigenetic States at Pericentromeric Heterochromatin.

26431676 - 2015-10-04
Trends Genet 2015 Nov;31(11):661-72

Déjardin J

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