Advancing Epigenetics Towards Systems Biology

Dirk Schübeler

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

Epigenetic modulation of genome function

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dirk schubeler

We are using mammalian stem cell models to ask how chromatin structure and DNA methylation influence gene regulation and genome organization. Towards this goal we combine molecular biology and functional genomic approaches. This enables us to monitor the epigenome and its dynamics in an unbiased way and to generate regulatory models from genome-wide datasets, which we test in cellular models by system perturbation and gene targeting.
Within EpiGeneSys we are particularly asking how DNA methylation states depend on the underlying sequence and the presence of transcription factor binding sites.

Latest publications

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

28473536 - 2017-05-06
Science 2017 May 5;356(6337)

Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J

Competition between DNA methylation and transcription factors determines binding of NRF1.

26675734 - 2015-12-18
Nature 2015 Dec 24;528(7583):575-9

Domcke S, Bardet AF, Adrian Ginno P, Hartl D, Burger L, Schübeler D

Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function.

26321660 - 2015-09-01
Cell Metab 2015 Oct 6;22(4):619-32

Avrahami D, Li C, Zhang J, Schug J, Avrahami R, Rao S, Stadler MB, Burger L, Schübeler D, Glaser B, Kaestner KH

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