Wellcome Trust Centre for Gene Regulation and Expression, The College of Life Sciences at the University of Dundee, UK
Nuclear structure and gene expression
The Lamond group uses a combination of quantitative approaches, including mass spectrometry based proteomics, advanced fluorescence microscopy and computational methods to study nuclear organisation, gene expression and protein dynamics. As part of the epigenesys network, we are particularly interested in the expression and interaction profiles of proteins and protein complexes involved in chromatin organisation. The complementarity of the approaches used enables us to study both global changes in the cellular proteome under different physiological conditions, such as during the cell cycle, differentiation or cellular stress, and to study individual protein interactions and their regulation to focus on specific biological regulatory mechanisms.