Advancing Epigenetics Towards Systems Biology

Angus Lamond

Wellcome Trust Centre for Gene Regulation and Expression, The College of Life Sciences at the University of Dundee, UK

Nuclear structure and gene expression

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angus lamond

The Lamond group uses a combination of quantitative approaches, including mass spectrometry based proteomics, advanced fluorescence microscopy and computational methods to study nuclear organisation, gene expression and protein dynamics. As part of the epigenesys network, we are particularly interested in the expression and interaction profiles of proteins and protein complexes involved in chromatin organisation. The complementarity of the approaches used enables us to study both global changes in the cellular proteome under different physiological conditions, such as during the cell cycle, differentiation or cellular stress, and to study individual protein interactions and their regulation to focus on specific biological regulatory mechanisms.

Latest publications

Comparative genetic, proteomic and phosphoproteomic analysis of C. elegans embryos with a focus on ham-1/STOX and pig-1/MELK in dopaminergic neuron development.

28659600 - 2017-07-01
Sci Rep 2017 Jun 28;7(1):4314

Offenburger SL, Bensaddek D, Murillo AB, Lamond AI, Gartner A

Brd4-Brd2 isoform switching coordinates pluripotent exit and Smad2-dependent lineage specification.

28588073 - 2017-06-08
EMBO Rep 2017 Jun 6;

Fernandez-Alonso R, Davidson L, Hukelmann J, Zengerle M, Prescott AR, Lamond A, Ciulli A, Sapkota GP, Findlay GM

Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation.

28077461 - 2017-01-13
EMBO Rep 2017 Mar;18(3):403-419

Hiraga SI, Ly T, Garzón J, Hořejší Z, Ohkubo YN, Endo A, Obuse C, Boulton SJ, Lamond AI, Donaldson AD

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