Advancing Epigenetics Towards Systems Biology

Edith Heard

CNRS/ Institut Curie, Paris, France

X chromosome inactivation

Web Page

edith heard edith heard group

The aim of the group of Edith Heard is to understand how cells can express their genomes differentially and in a stable, although sometimes reversible, manner during development, using X-chromosome inactivation as our model. X inactivation is a normal process, entailing the silencing of one of the two X chromosomes in female mammals. Once established the silent state is stably maintained through cell divisions and throughout the adult life, but can be reversed at certain stages of development, in the germ line and possibly in cancer cells. Studying the process of X chromosome inactivation should allow us to unveil the molecular mechanisms involved in establishing, maintaining and reversing heterochromatin. We are interested (1) in what underlies the control of the initiation of X-chromosome inactivation, (2) in how transcriptional repression is established and (3) in how the inactive state is faithfully inherited through cellular division. In the context of Epigenesys, we are investigating the cis- and trans-regulatory network that controls the initiation of X inactivation.

Lab members:

  • Katia Ancelin
  • Mikael Attia
  • Maud Borensztein
  • Ronan Chaligné
  • Chongjian Chen
  • Catherine Corbel
  • Patricia Diabangouaya
  • Martin Escamilla del Arenal
  • Anne-Valerie Gendrel
  • Luca Giorgetti
  • Camille Granier
  • Elphège-Pierre Nora
  • Christel Picard
  • Tim Pollex
  • Edda Schulz
  • Simao T da Rocha

Related video to Edith Heard:

Latest publications

X chromosome inactivation: new players in the initiation of gene silencing.

28408975 - 2017-04-15
F1000Res 2017;6

Pinheiro I, Heard E

Landscape of monoallelic DNA accessibility in mouse embryonic stem cells and neural progenitor cells.

28112738 - 2017-01-24
Nat Genet 2017 Mar;49(3):377-386

Xu J, Carter AC, Gendrel AV, Attia M, Loftus J, Greenleaf WJ, Tibshirani R, Heard E, Chang HY

XACT Noncoding RNA Competes with XIST in the Control of X Chromosome Activity during Human Early Development.

27989768 - 2016-12-19
Cell Stem Cell 2016 Dec 1;

Vallot C, Patrat C, Collier AJ, Huret C, Casanova M, Liyakat Ali TM, Tosolini M, Frydman N, Heard E, Rugg-Gunn PJ, Rougeulle C

View all their publications