Advancing Epigenetics Towards Systems Biology

Wolf Reik

The Babraham Institute, Cambridge, United Kingdom

Epigenetic reprogramming in mammalian development

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wolf reik

We are interested in epigenetic reprogramming in mammalian development, which occurs on a large scale in primordial germ cells and early embryos. Reprogramming probably has important roles in erasing parental imprints, returning the genome to a pluripotent state, removing acquired epimutations, and is potentially also important for the control of transposons. We are particularly interested in genome-wide erasure of DNA methylation, which may occur by a combination of mechanisms including passive demethylation, modification of methylcytosine by deamination or oxidation, and DNA repair.  We are studying the dynamics of these novel DNA modifications by genome-wide profiling techniques during ES cell differentiation, and during experimental reprogramming to iPS cells. Some of the dynamics associated with early lineage decisions and reprogramming may lend themselves to computational and modeling approaches.

People involved in the lab:

  • Tim Hore, postdoc

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Latest publications

Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

28538171 - 2017-05-26
Cell Rep 2017 May 23;19(8):1503-1511

Kirschner K, Chandra T, Kiselev V, Flores-Santa Cruz D, Macaulay IC, Park HJ, Li J, Kent DG, Kumar R, Pask DC, Hamilton TL, Hemberg M, Reik W, Green AR

Erratum to: DeepCpG: accurate prediction of single-cell DNA methylation states using deep learning.

28499443 - 2017-05-14
Genome Biol 2017 May 12;18(1):90

Angermueller C, Lee HJ, Reik W, Stegle O

Multi-tissue DNA methylation age predictor in mouse.

28399939 - 2017-04-13
Genome Biol 2017 Apr 11;18(1):68

Stubbs TM, Bonder MJ, Stark AK, Krueger F, BI Ageing Clock Team., von Meyenn F, Stegle O, Reik W

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