Advancing Epigenetics Towards Systems Biology

Geneviève Almouzni

Nuclear Dynamics – Institut Curie/CNRS UMR 3664, Paris, France

Organisation of Heterochromatin Domains

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genevieve almouzni

 

The Almouzni lab's major scientific objective will be to gain data enabling researchers to model nucleosome assembly with distinct variants and organisation of heterochromatin domains, to assess their plasticity/stability throughout the cell cycle and when challenged under various perturbations. For this, the Almouzni lab will use biochemical and cellular assays involving protein complexes (such as recombinant histone chaperones, histone H3 variants, HP1, epitope tagged in vivo) to study the dynamics and modifications of histone H3 variants and heterochromatin proteins during the cell cycle.

PhD students: Post-docs:
Emmanuelle SZENKER
Paolo BEUZER
Kelly ROMEO
Dan FILIPESCU
Salomé ADAM
FR
IT
FR
RO
FR
  Ekaterina BOYARCHUK
Miguel CASANOVA
Zachary GURARD-LEVIN
Sebastian MÜLLER
Rocio MONTES DE OCA
Lisa PRENDERGAST
Gaston SORIA
Adam WOOLFE
RU
PT
USA
DE
MX
IE
AR
UK

Latest publications

Essential role for centromeric factors following p53 loss and oncogenic transformation.

28356341 - 2017-03-31
Genes Dev 2017 Mar 1;31(5):463-480

Filipescu D, Naughtin M, Podsypanina K, Lejour V, Wilson L, Gurard-Levin ZA, Orsi GA, Simeonova I, Toufektchan E, Attardi LD, Toledo F, Almouzni G

Insights into the molecular architecture and histone H3-H4 deposition mechanism of yeast Chromatin assembly factor 1.

28315525 - 2017-03-21
Elife 2017 Mar 18;6

Sauer PV, Timm J, Liu D, Sitbon D, Boeri-Erba E, Velours C, Mücke N, Langowski J, Ochsenbein F, Almouzni G, Panne D

Chromatin dynamics during the cell cycle at centromeres.

28138144 - 2017-02-01
Nat Rev Genet 2017 Mar;18(3):192-208

Müller S, Almouzni G

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