Department of Cancer Biology at the at UCL Cancer Institute, University College London, UK
Epigenomics in Health & Disease
The Beck lab has broad interests in the genomics and epigenomics of phenotypic plasticity in health and disease. In addition to genetic variations, we study epigenetic variations such as DNA methylation, histone modifications and microRNAs and how they modulate genome function. Central to our research is the development of systems approaches for integration of multi-dimensional data and their application to epigenome-wide association studies (EWAS) in cancer and other common diseases to advance translational, regenerative and personalized medicine. Our contribution to EpiGeneSys is to explore and quantify the link between genotype and epigenotype in the context of common disease.