Advancing Epigenetics Towards Systems Biology

Miguel Constância

University of Cambridge - Metabolic Research Laboratories - MRC Metabolic Diseases Unit - Department of Obstetrics & Gynaecology

Epigenetic programming of growth and metabolism across the life-course

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miguel constancia miguel constancia group

Appropriate allocation of maternal resources to the offspring is critical for successful reproduction, fetal and infant growth. Furthermore, the nutritional environment in which the mammalian fetus or infant develops influences the risk of chronic diseases, such as type 2 diabetes (T2D) and obesity. However, the precise molecular mechanisms by which the early environment influences long-term metabolic health across the life-course remain poorly defined. The global aim of our research is to establish novel mechanistic principles that underlie the early origins of metabolic disease using (epi)genome-wide technologies and systems biology approaches. We aim to: 1) define the signalling networks that operate between the fetus, the placenta and the mother to control resource allocation and growth; 2) to define (epi)genetic mechanisms by which early-life growth impairment alters maternal and offspring metabolism; 3) to establish the effects of maternal diet and age on epigenetically regulated promoter enhancer interactions across the genome.

Team:

  • Wendy Cooper (post-doc)
  • Ionel Sandovici (post-doc)
  • Laura Kusinski (post-doc)
  • Niahm Campbell (PhD student)
  • Constanze Hammerle (PhD student)

Latest publications

Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets.

26699651 - 2015-12-25
Diabetologia 2015 Dec 23;

Sandovici I, Hammerle CM, Cooper WN, Smith NH, Tarry-Adkins JL, Dunmore BJ, Bauer J, Andrews SR, Yeo GS, Ozanne SE, Constância M

Intergenerational epigenetic inheritance in models of developmental programming of adult disease.

26135290 - 2015-07-03
Semin Cell Dev Biol 2015 Jun 30;

Fernandez-Twinn DS, Constância M, Ozanne SE

Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion.

25560321 - 2015-01-07
Cardiovasc Res 2015 Jan 5;

Shen H, Cavallero S, Estrada KD, Sandovici I, Kumar SR, Makita T, Lien C, Constancia M, Sucov HM

View all their publications