An ambitious EC-funded research initiative on epigenetics advancing towards systems biology

University of Glasgow

Description

Supervisors: Adam West and David Vetrie

You will be responsible for providing key bioinformatics support and research activities to the West and Vetrie research groups, the aims of which are to address fundamental questions about the chromosomal domain organisation of human cells and the regulatory processes that control the expression of genes during mammalian haematopoietic development. Further details of the work in our groups can be found at www.gla.ac.uk/researchinstitutes/cancersciences/research/epigenetics.

Relevant publications:

1. Hassan-Zadeh V, Chilaka S, Cadoret JC, Ma MK, Boggetto N, West AG and Prioleau MN. USF binding sequences from the HS4 insulator element impose early replication timing on a vertebrate replicator. PLoS Biol. 2012, 10:e1001277.
2. Ma MK, Heath C, Hair A and West AG. Histone crosstalk directed by H2B ubiquitination is required for chromatin boundary integrity. PLoS Genet. 2011 7:e1002175.
3. Dhami P et al. Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution. PLoS One. 2010, 5:e12339.
4. Dhami P et al. Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus. PLoS One. 2010, 5:e9059.
5. Dickson J, Gowher H, Strogantsev R, Gaszner M, Hair A, Felsenfeld G and West AG. VEZF1 elements mediate protection from DNA methylation. PLoS Genet. 2010, 6:e1000804.
6. Bruce AW et al. Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level. Genome Res. 2009, 19:994-1005.
7. ENCODE Project Consortium. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007 447(7146):799-816.
8. Koch CM et al. The landscape of histone modifications across 1% of the human genome in five human cell lines. Genome Res. 2007, 17:691-707.

Qualifications

Knowledge/Qualifications
Essential:
A1. BSc in scientific discipline
A2. Knowledge of relevant resources for data-mining for genome-scale analyses
A3. Theoretical knowledge of basic principles of mammalian gene regulation
A4. Theoretical knowledge of expression and CHIP-chip microarray analysis
A5. Knowledge of biological analysis pipelines
For appointment at Grade 7:
A6. PhD in biological or bioinformatics/computational science.

Salary

Salary will be on the University’s Research and Teaching Grade 6 (26,004 – £29,249) or Grade 7 (£31,948 – £35,938) per annum depending on experience.

The funding for this post is available immediately and is for 3 years in the first instance.

Application details

Go to group website at www.adamwest.co.uk to download a full job description and study group projects.

Applications must be made online at www.glasgow.ac.uk/jobs.

Closing date: 20 August 2012.