Epigenetics in alternative splicing regulation
|Friday, 27 April 2012 23:23|
Institut de Genetique Humaine
Alternative splicing is an important process to generate protein diversity that affects the vast majority of human genes. Misregulation of cell-specific splicing programs can lead to disease, such as cancer. In the past few years, transcriptional regulators, chromatin conformation, histone modifications and non-coding RNAs have been shown to play a role in the regulation of alternative splicing (Luco et al, 2011 Cell). We recently found that histone marks directly regulate alternative splicing via recruitment of splicing factors by chromatin-adaptor complexes (Luco et al, 2010 Science). To continue these studies in my laboratory at the Institute of Human Genetics (IGH-CNRS), I am looking for a highly motivated, independent and creative post-doctoral fellow with strong background in molecular and cell biology. IGH is a very stimulating international institute in an extremely charming and sunny city, Montpellier (South of France).
PhD degree, good English, collaborative and motivated personality
If interested, please send a CV, e-mail contact for three reference letters and a brief cover letter stating research interests and career goals to :
Starting date: 2012-05-01
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