An ambitious EC-funded research initiative on epigenetics advancing towards systems biology

RWTH University Hospital

Description

The Computational Biology Group of Interdisciplinary Center for Clinical Research (IZKF) Aachen, RWTH Aachen University Hospital, Aachen, invites applicants for a PhD candidate position in the area of computational biology methods for gene regulation and epigenetics on cell differentiation.

The project is based on the integrative analysis of expression, transcription factor binding and epigenetic data to understand regulatory processes behind cell differentiation and the onset of diseases. We are particularly interested in using hidden Markov models for the segmentation of genomic regions given their epigenetic profiles to characterize genomic regions and their roles in gene regulation during cell differentiation. This project will be performed in collaboration with the Institute for Biomedical Engineering, Department of Cell Biology, RWTH Aachen University Hospital, which is interested in the study of antigen presenting dendritic cell development.

Qualifications

Applicants should hold a M.Sc. or equivalent degree in Bioinformatics, Computer Science or related areas. Experience in the analysis of gene expression, transcription factor binding and ChIP-Seq is desirable. The candidate should have solid programming skills (C, Python and R) and acquaintance with Linux (high performance computing is a plus). The working language of the group is English.

Salary

The position is based on the German TV-L 13 salary scale, including all German social benefits (health insurance and pension scheme).

Application details

Interested candidates should send a CV and the names of two references to:
Ivan G. Costa - This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Relavant web link: http://www.costalab.org

Starting date: 2012-09-01
Closing date: 2012-07-15