An ambitious EC-funded research initiative on epigenetics advancing towards systems biology

A kind of cancer of the bone marrow, which involves uncontrolled proliferation of abnormal white blood cells. Symptoms present in both and adults and children. These include anaemia, impaired blood-clotting, enlargement of lymph nodes, liver and spleen.

(latin, plural loci) A locus is a fixed position on a chromosome that is occupied by a given gene or one of its alleles.

(LCR) Defined by their ability to enhance the expression of linked genes to physiological levels in a tissue-specific and copy number-dependent manner at ectopic chromatin sites. The concept that developmental and cell lineage-specific regulation of gene expression relies not only on gene-proximal elements such as promoters, enhancers, and silencers, but also on long-range interactions of various cis regulatory elements and dynamic chromatin alterations.

States that in cells with multiple X chromosomes, all but one is inactivated during mammalian embryogenesis.

One of the twenty different kinds of amino acid. Specific lysines within histone proteins are those most often tagged by acetyl, methyl and other biochemical moieties.