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... first year of marriage, the Coris collaborated on a study of the immune bodies in blood. They both accepted positions at the University of Vienna and Gerty subsequently spent two years at the Karolinen-Kinderspital der Stadt Wien, working on the problem of temperature regulation in congenital myxoedema before and after thyroid therapy. The Coris soon ...
Section: Content | Category: Women in science | Date: Monday, 22 April 2013 | Hits: 5035
... and egg, is the epigenetic modification the cause or the consequence? But, one thing is certain: at the DNA level things change with age, and we need to find out what is changing and why. And, as Eric Greer explains, epigenetics may give us the answers. "I think that epigenetics provides another layer in the regulation of aging". Comments: 3. http://news.sciencemag.org/sciencenow/2012/12/smoking-smothers-your-genes.html 4. ...
Section: Content | Category: Features | Date: Thursday, 18 July 2013 | Hits: 23191
... analysis of repetitive elements is really challenging. Our collaboration actually started at one of the EpiGeneSys annual meetings, which put Juanma and I in contact in a very stimulating environment. Because we are both RISE members, I guess it was 'natural' to undertake this collaboration together. Apart from our findings on chromatin regulation for ...
Section: Content | Category: News | Date: Wednesday, 19 August 2015 | Hits: 4462
... adapt to the diverse aspects of our life such as embryonic development, ageing, response to diet, learning or environmental stress, it is now proposed that distinct changes in the 3D arrangement of our genomes occur. These changes are coordinated through regulation of gene expression. Just as a map of the world is more than a mere list of places and ...
Section: Content | Category: News | Date: Tuesday, 03 May 2016 | Hits: 2338
... eng) Cell 128(4):635-638 (in eng). 3. Berger SL (2007) The complex language of chromatin regulation during transcription. (Translated from eng) Nature 447(7143):407-412 (in eng). 4. Taverna SD, Li H, Ruthenburg AJ, Allis CD, & Patel DJ (2007) How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. (Translated ...
Section: Content | Category: Features | Date: Tuesday, 05 March 2013 | Hits: 15327
Imagine that you are on a journey, visiting the nucleus of a cell of the human body. We can think of the nucleus as the "inner city". In terms of activity, the inner city resembles an ant colony on caffeine—it's incredibly busy How does the cell know what parts of the information to access in order to produce what it needs? November 2012 Written ...
Section: Content | Category: Features | Date: Wednesday, 14 November 2012 | Hits: 34462
... showing that this enzyme is actually bound to a protein that is made in certain leukaemias and is involved in the misregulation of gene expression. So a finding in yeast was used to identify a protein in mammals that has now been shown to be involved in leukaemia," Fred comments. These proteins when bound result in too much methylation on this histone. ...
Section: Content | Category: Features | Date: Friday, 01 August 2008 | Hits: 38767
... are necessary to tease DNA away from nucleosomes, little histone bundles also described (at least in part) by Kornberg. These basic units of chromatin (seen as beads on a string in the picture above) are common to most cells with a nucleus i.e. not bacteria, and are instrumental in gene regulation. Around 150 base-pairs of DNA encircle every histone ...
Section: Content | Category: In brief | Date: Monday, 02 October 2006 | Hits: 19202
9. Primed
... differentiate along specialised lineages. A good analogy is the difference between a car sitting at a red traffic light with its engine revved up, and trying to start a car from cold on a frosty winter morning. A study carried out by the Gene Regulation and Chromatin Group at the MRC Clinical Sciences Centre, led by Niall Dillon, has provided new information ...
Section: Content | Category: In brief | Date: Tuesday, 01 June 2010 | Hits: 12581
... gene regulation. An important feature of DNA methylation is that it can be faithfully copied during the process of DNA replication, i.e. when cells double their chromosomes in readiness for cell division. This provides a nice example of how epigenetic information is transmitted from one cell generation to the next. DNA methylation occurs in many, but ...
Section: Content | Category: Features | Date: Friday, 01 August 2008 | Hits: 34294