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Department of Biochemistry, Oxford University

Chromatin remodeling and gene regulation in simple eukaryotes

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jane mellorjane mellor group

The Mellor group is interested in how the action of chromatin modifying enzymes influences the yeast metabolic cycle, managing the balance between growth and longevity. Maintaining this balance is critical for healthy ageing at the cellular and organismal level. One aim is to understand how switches in the composition of the SAGA complex, particularly Spt7, influences the activities associated with the complex. The group will combine experimental analysis and iterative modelling to describe how the complex changes as growth rate changes and in response to nutrient regulated signal transduction pathways (TORC1 and AMPK) and extend this work into worms and mammals.

PhDs and Postdocs involved in research on EpiGeneSys projects:

  • Dr Ivan Boubriak
  • Mr Struan Murray
  • Mr Harry Fischl
  • Ms Karolina Chiocan
  • Dr Francoise Howe

Latest publications

The clinical effectiveness and cost-effectiveness of STeroids Or Pentoxifylline for Alcoholic Hepatitis (STOPAH): a 2 × 2 factorial randomised controlled trial.

26691209 - 2015-12-23
Health Technol Assess 2015 Dec;19(102):1-104
Thursz M, Forrest E, Roderick P, Day C, Austin A, O'Grady J, Ryder S, Allison M, Gleeson D, McCune A, Patch D, Wright M, Masson S, Richardson P, Vale L, Mellor J, Stanton L, Bowers M, Ratcliffe I, Downs N, Kirkman S, Homer T, Ternent L

The Interleaved Genome.

26613890 - 2015-11-29
Trends Genet 2016 Jan;32(1):57-71
Mellor J, Woloszczuk R, Howe FS

Sense and antisense transcription are associated with distinct chromatin architectures across genes.

26130720 - 2015-07-02
Nucleic Acids Res 2015 Jun 29;
Murray SC, Haenni S, Howe FS, Fischl H, Chocian K, Nair A, Mellor J

View all their publications

News flash

Epigenetic switch for obesity

08-02-2016 - All News

Obesity can sometimes be shut down It is well known that a predisposition to adiposity lies in our genes. A new study by researchers at the Max Planck Institute of Immunobiology...

EpiGeneSys in the News

19-02-2015 - All News

Today special issue of Nature about the main findings of the NIH Roadmap Epigenomics Program, the aim of which was to systematically characterize epigenomic landscapes in primary human tissues and...