Department of Biochemistry, Oxford University

Chromatin remodeling and gene regulation in simple eukaryotes

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jane mellorjane mellor group

The Mellor group is interested in how the action of chromatin modifying enzymes influences the yeast metabolic cycle, managing the balance between growth and longevity. Maintaining this balance is critical for healthy ageing at the cellular and organismal level. One aim is to understand how switches in the composition of the SAGA complex, particularly Spt7, influences the activities associated with the complex. The group will combine experimental analysis and iterative modelling to describe how the complex changes as growth rate changes and in response to nutrient regulated signal transduction pathways (TORC1 and AMPK) and extend this work into worms and mammals.

PhDs and Postdocs involved in research on EpiGeneSys projects:

  • Dr Ivan Boubriak
  • Mr Struan Murray
  • Mr Harry Fischl
  • Ms Karolina Chiocan
  • Dr Francoise Howe

Latest publications

Is H3K4me3 instructive for transcription activation?

28004446 - 2016-12-23
Bioessays 2017 Jan;39(1):1-12
Howe FS, Fischl H, Murray SC, Mellor J

Using both strands: The fundamental nature of antisense transcription.

26760777 - 2016-01-14
Bioarchitecture 2016 Jan 2;6(1):12-21
Murray SC, Mellor J

The Interleaved Genome.

26613890 - 2015-11-29
Trends Genet 2016 Jan;32(1):57-71
Mellor J, Woloszczuk R, Howe FS

View all their publications

News flash

Missing link in epigenetics could explain conundrum of disease inheritance

08-07-2016 - All News

The process by which a mother’s diet during pregnancy can permanently affect her offspring’s attributes, such as weight, could be strongly influenced by genetic variation in an unexpected part of...

Epigenetic switch for obesity

08-02-2016 - All News

Obesity can sometimes be shut down It is well known that a predisposition to adiposity lies in our genes. A new study by researchers at the Max Planck Institute of Immunobiology...