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Jane Mellor

Department of Biochemistry, Oxford University

Chromatin remodeling and gene regulation in simple eukaryotes

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jane mellorjane mellor group

The Mellor group is interested in how the action of chromatin modifying enzymes influences the yeast metabolic cycle, managing the balance between growth and longevity. Maintaining this balance is critical for healthy ageing at the cellular and organismal level. One aim is to understand how switches in the composition of the SAGA complex, particularly Spt7, influences the activities associated with the complex. The group will combine experimental analysis and iterative modelling to describe how the complex changes as growth rate changes and in response to nutrient regulated signal transduction pathways (TORC1 and AMPK) and extend this work into worms and mammals.

PhDs and Postdocs involved in research on EpiGeneSys projects:

  • Dr Ivan Boubriak
  • Mr Struan Murray
  • Mr Harry Fischl
  • Ms Karolina Chiocan
  • Dr Francoise Howe

Latest publications

Lysine acetylation controls local protein conformation by influencing proline isomerization.

25127513 - 2014-08-16
Mol Cell 2014 Sep 4;55(5):733-44
Howe FS, Boubriak I, Sale MJ, Nair A, Clynes D, Grijzenhout A, Murray SC, Woloszczuk R, Mellor J

Analysis of C. elegans intestinal gene expression and polyadenylation by fluorescence-activated nuclei sorting and 3'-end-seq.

22467213 - 2012-04-03
Nucleic Acids Res 2012 Mar 29;
Haenni S, Ji Z, Hoque M, Rust N, Sharpe H, Eberhard R, Browne C, Hengartner MO, Mellor J, Tian B, Furger A

A pre-initiation complex at the 3'-end of genes drives antisense transcription independent of divergent sense transcription.

22123739 - 2011-11-30
Nucleic Acids Res 2012 Mar;40(6):2432-44
Murray SC, Serra Barros A, Brown DA, Dudek P, Ayling J, Mellor J

View all their publications

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