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Jane Mellor

Department of Biochemistry, Oxford University

Chromatin remodeling and gene regulation in simple eukaryotes

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The Mellor group is interested in how the action of chromatin modifying enzymes influences the yeast metabolic cycle, managing the balance between growth and longevity. Maintaining this balance is critical for healthy ageing at the cellular and organismal level. One aim is to understand how switches in the composition of the SAGA complex, particularly Spt7, influences the activities associated with the complex. The group will combine experimental analysis and iterative modelling to describe how the complex changes as growth rate changes and in response to nutrient regulated signal transduction pathways (TORC1 and AMPK) and extend this work into worms and mammals.

PhDs and Postdocs involved in research on EpiGeneSys projects:

  • Dr Ivan Boubriak
  • Mr Struan Murray
  • Mr Harry Fischl
  • Ms Karolina Chiocan
  • Dr Francoise Howe

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How, in some cancers, a protein excess could induce treatments resistance

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Scientists demonstrate a role for epigenetics in the inheritance of complex traits

17-02-2014 All News

Scientists demonstrate a role for epigenetics in the inheritance of complex traits

The teams of Vincent Colot at the Institut de Biologie de l'Ecole Normale Supérieure (IBENS) in Paris (France) and Frank Johannes at the Groningen Bioinformatics Centre [GBiC] (University of Groningen...